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Cytochrome P450 monooxygenase specific activity reduction in wheat

Kangxin HE,Qixing ZHOU

《环境科学与工程前沿（英文）》 2016年第10卷第2期页码 270-275 doi: 10.1007/s11783-015-0813-y

摘要： Roxithromycin, as widely used medicine and livestock growth promoter, arouses concern because its occurrence and persistence in soil environments. However, effects of roxithromycin in higher plants are still vague. Accordingly, we hypothesized that roxithromycin-contaminated soil may exhibits ecotoxicological effects in wheat ( ). In this study, effects induced by a gradient concentration of roxithromycin stress (0.01, 0.1, 1, 10, and 100 mg·kg ) was investigated in a 7-d soil test in . Results indicated that the specific activity of cytochrome P450 (CYP450) monooxygenase was decreased dramatically with the concentration of roxithromycin in soil. The IC value was 8.78 mg·kg of roxithromycin. On the contrary, the growth related endpoints (i.e., the germination percentage, the biomass and the height), the content related endpoints (i.e., soluble protein content and CYP450 content), and the superoxide dismutase (SOD) activity failed to reveal the roxithromycin-induced effects. Further analysis revealed that the CYP450 monooxygenase specific activity reduction was enzymatic mechanism mediated, other than oxidative stress induced. We conclude that the soil roxithromycin declined the CYP450 monooxygenase activity in by the inhibition of the enzymatic mechanism. Further efforts can include, but are not limited to, investigation of joint effects induced by combined exposure of roxithromycin and the pesticides and evaluation of the similar effects in other higher plants.

关键词： roxithromycin toxic effect cytochrome P450 monooxygenase soil environment Triticum aestivum biomarker

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利用异源酶组合构建酿酒酵母中咖啡酸的生物合成 Article

刘岚清, 刘宏, 张伟, 姚明东, 李炳志, 刘夺, 元英进

《工程（英文）》 2019年第5卷第2期页码 287-295 doi: 10.1016/j.eng.2018.11.029

摘要： <p>微生物中构建植物源天然产物的生物合成面临着许多挑战，尤其是当需要表达与激活植物源细胞色素P450酶的时候。通过从几种细菌中筛选HpaB和HpaC两种酶，本文在酿酒酵母中构建了具有活性的4-羟基苯乙酸3-羟化酶（4 HPA3H），它可以发挥植物源细胞色素P450酶的相似作用，用于生产咖啡酸。p>

关键词：酿酒酵母咖啡酸异源酶细胞色素P450酶合成生物学

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Impacts of n-alkane concentration on soil bacterial community structure and alkane monooxygenase genes

Yueqiao Liu, Aizhong Ding, Yujiao Sun, Xuefeng Xia, Dayi Zhang

《环境科学与工程前沿（英文）》 2018年第12卷第5期 doi: 10.1007/s11783-018-1064-5

摘要：

Soil microbial community is not significantly shaped by alkane concentrations

Alkane concentrations alter dominant alkane degraders in soils

Different alkanes are preferentially degraded at different contamination level

Different types of alkane monooxygenase genes responsible for alkane degradation

关键词： Petroleum hydrocarbon contaminated site n-alkane contamination level n-alkane biodegradation Soil bacterial community Alkane degraders Alkane-monooxygenase genes

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摩尔定律发展亟需450 mm 硅片但时间可能会推迟

屠海令

《工程（英文）》 2015年第1卷第2期页码 162-163 doi: 10.15302/J-ENG-2015060

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construction integration technology in Brazil’s superlarge deep-water offshore oil and gas unit project (FPSO P67/P70)

《工程管理前沿（英文）》 2022年第9卷第2期页码 349-353 doi: 10.1007/s42524-022-0187-3

关键词： Brazil FPSO P67/P70 superlarge dry towing operation construction integration risk control management

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P2P energy trading via public power networks: Practical challenges, emerging solutions, and the way forward

《能源前沿（英文）》 2023年第17卷第2期页码 189-197 doi: 10.1007/s11708-023-0873-9

摘要： Peer-to-peer (P2P) energy trading is an emerging energy supply paradigm where customers with distributed energy resources (DERs) are allowed to directly trade and share electricity with each other. P2P energy trading can facilitate local power and energy balance, thus being a potential way to manage the rapidly increasing number of DERs in net zero transition. It is of great importance to explore P2P energy trading via public power networks, to which most DERs are connected. Despite the extensive research on P2P energy trading, there has been little large-scale commercial deployment in practice across the world. In this paper, the practical challenges of conducting P2P energy trading via public power networks are identified and presented, based on the analysis of a practical Local Virtual Private Networks (LVPNs) case in North Wales, UK. The ongoing efforts and emerging solutions to tackling the challenges are then summarized and critically reviewed. Finally, the way forward for facilitating P2P energy trading via public power networks is proposed.

关键词： distribution network local virtual private network network charges peer-to-peer (P2P) energy trading practical implementation.

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Solomon P Wasser：蕈菌的药用（2019年9月19日）

Solomon P Wasser(高级职称)

2021年01月20日

关键词：农业科学

面向服务的P2P网络体系结构层次参考模型研究

刘业,刘林峰,庄艳艳

《中国工程科学》 2007年第9卷第9期页码 72-77

摘要： <p style="text-align: justify;">提出了一种基于交互、面向服务的P2P网络体系结构框架模型ISPNA，同时结合P2P网络松耦合、自组织、可缩放等特点，对P2P网络技术中增强其可用性需从P2P网络体系结构的研究角度出发，将增强P2P网络可用性所需要考虑的多方面因素放置在P2P网络的不同层次予以解决，有利于从宏观上把握需要解决的问题。p>

关键词： P2P网络体系结构层次参考模型资源服务

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Probes and nano-delivery systems targeting NAD(P)H:quinone oxidoreductase 1: a mini-review

《化学科学与工程前沿（英文）》 2023年第17卷第2期页码 123-138 doi: 10.1007/s11705-022-2194-7

摘要： The two-electron cytoplasmic reductase NAD(P)H:quinone oxidoreductase 1 is expressed in many tissues. NAD(P)H:quinone oxidoreductase 1 is well-known for being highly expressed in most cancers. Therefore, it could be a target for cancer therapy. Because it is a quinone reductase, many bioimaging probes based on quinone structures target NAD(P)H:quinone oxidoreductase 1 to diagnose tumours. Its expression is higher in tumours than in normal tissues, and using target drugs such as β-lapachone to reduce side effects in normal tissues can help. However, the physicochemical properties of β-lapachone limit its application. The problem can be solved by using nanosystems to deliver β-lapachone. This mini-review summarizes quinone-based fluorescent, near-infrared and two-photon fluorescent probes, as well as nanosystems for delivering the NAD(P)H:quinone oxidoreductase 1-activating drug β-lapachone. This review provides valuable information for the future development of probes and nano-delivery systems that target NAD(P)H:quinone oxidoreductase 1.

关键词： NAD(P)H:quinone oxidoreductase 1 cancer therapy target probe nanosystem

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Fine-grained P2P traffic classification by simply counting flows

Jie HE,Yue-xiang YANG,Yong QIAO,Wen-ping DENG

《信息与电子工程前沿（英文）》 2015年第16卷第5期页码 391-403 doi: 10.1631/FITEE.1400267

摘要： The continuous emerging of peer-to-peer (P2P) applications enriches resource sharing by networks, but it also brings about many challenges to network management. Therefore, P2P applications monitoring, in particular, P2P traffic classification, is becoming increasingly important. In this paper, we propose a novel approach for accurate P2P traffic classification at a fine-grained level. Our approach relies only on counting some special flows that are appearing frequently and steadily in the traffic generated by specific P2P applications. In contrast to existing methods, the main contribution of our approach can be summarized as the following two aspects. Firstly, it can achieve a high classification accuracy by exploiting only several generic properties of flows rather than complicated features and sophisticated techniques. Secondly, it can work well even if the classification target is running with other high bandwidth-consuming applications, outperforming most existing host-based approaches, which are incapable of dealing with this situation. We evaluated the performance of our approach on a real-world trace. Experimental results show that P2P applications can be classified with a true positive rate higher than 97.22% and a false positive rate lower than 2.78%.

关键词： Traffic classification Peer-to-peer (P2P) Fine-grained Host-based

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Q&P 工艺理念在热轧先进高强度钢中的应用研究

袁国,康健,张贺,李云杰,胡虹玲,王国栋

《中国工程科学》 2014年第16卷第1期页码 59-65

摘要： <p>为满足汽车工业轻量化发展要求，以Q&P（quenching & partitioning）工艺为基础的先进高强度钢受到了广泛关注，为使其在普通热连轧生产线上实现工业化并广泛应用，本文对Q&P理念在热轧工艺中的应用进行了基础研究。结果表明在传统热处理Q&P工艺中引入热变形处理后，组织细化显著，并获得了一定量的残余奥氏体。）&P钢）的可行性。p>

关键词：先进高强度钢 Q&P DQ&P 热轧残余奥氏体

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UV-LED/P25-based photocatalysis for effective degradation of isothiazolone biocide

《环境科学与工程前沿（英文）》 2021年第15卷第5期 doi: 10.1007/s11783-020-1379-x

摘要：

• UV-LED with shorter wavelength was beneficial for photocatalytic degradation.

关键词： Degradation Photocatalytic LED CMIT P25

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Comparison of modeling methods for wind power prediction: a critical study

Rashmi P. SHETTY, A. SATHYABHAMA, P. Srinivasa PAI

《能源前沿（英文）》 2020年第14卷第2期页码 347-358 doi: 10.1007/s11708-018-0553-3

摘要： Prediction of power generation of a wind turbine is crucial, which calls for accurate and reliable models. In this work, six different models have been developed based on wind power equation, concept of power curve, response surface methodology (RSM) and artificial neural network (ANN), and the results have been compared. To develop the models based on the concept of power curve, the manufacturer’s power curve, and to develop RSM as well as ANN models, the data collected from supervisory control and data acquisition (SCADA) of a 1.5 MW turbine have been used. In addition to wind speed, the air density, blade pitch angle, rotor speed and wind direction have been considered as input variables for RSM and ANN models. Proper selection of input variables and capability of ANN to map input-output relationships have resulted in an accurate model for wind power prediction in comparison to other methods.

关键词： power curve method of least squares cubic spline interpolation response surface methodology artificial neural network (ANN)

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noncoding RNA LOC646029 functions as a ceRNA to suppress ovarian cancer progression through the miR-627-3p/

《医学前沿（英文）》页码 924-938 doi: 10.1007/s11684-023-1004-z

摘要： Long noncoding RNAs (lncRNAs) play a crucial regulatory role in the development and progression of multiple cancers. However, the potential mechanism by which lncRNAs affect the recurrence and metastasis of ovarian cancer remains unclear. In the current study, the lncRNA LOC646029 was markedly downregulated in metastatic ovarian tumors compared with primary tumors. Gain- and loss-of-function assays demonstrated that LOC646029 inhibits the proliferation, invasiveness, and metastasis of ovarian cancer cells in vivo and in vitro. Moreover, the downregulation of LOC646029 in metastatic ovarian tumors was strongly correlated with poor prognosis. Mechanistically, LOC646029 served as a miR-627-3p sponge to promote the expression of Sprouty-related EVH1 domain-containing protein 1, which is necessary for suppressing tumor metastasis and inhibiting KRAS signaling. Collectively, our results demonstrated that LOC646029 is involved in the progression and metastasis of ovarian cancer, which may be a potential prognostic biomarker.

关键词： ovarian cancer lncRNA LOC646029 metastasis microRNA 627-3p SPRED1

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FMO3--TMAO axis modulates the clinical outcome in chronic heart-failure patients with reduced ejection fraction: evidence from an Asian population

《医学前沿（英文）》 2022年第16卷第2期页码 295-305 doi: 10.1007/s11684-021-0857-2

摘要： The association among plasma trimethylamine-N-oxide (TMAO), FMO3 polymorphisms, and chronic heart failure (CHF) remains to be elucidated. TMAO is a microbiota-dependent metabolite from dietary choline and carnitine. A prospective study was performed including 955 consecutively diagnosed CHF patients with reduced ejection fraction, with the longest follow-up of 7 years. The concentrations of plasma TMAO and its precursors, namely, choline and carnitine, were determined by liquid chromatography-mass spectrometry, and the FMO3 E158K polymorphisms (rs2266782) were genotyped. The top tertile of plasma TMAO was associated with a significant increment in hazard ratio (HR) for the composite outcome of cardiovascular death or heart transplantation (HR=1.47, 95% CI=1.13–1.91, P=0.004) compared with the lowest tertile. After adjustments of the potential confounders, higher TMAO could still be used to predict the risk of the primary endpoint (adjusted HR=1.33, 95% CI=1.01–1.74, P=0.039). This result was also obtained after further adjustment for carnitine (adjusted HR=1.33, 95% CI=1.01–1.74, P=0.039). The FMO3 rs2266782 polymorphism was associated with the plasma TMAO concentrations in our cohort, and lower TMAO levels were found in the AA-genotype. Thus, higher plasma TMAO levels indicated increased risk of the composite outcome of cardiovascular death or heart transplantation independent of potential confounders, and the FMO3 AA-genotype in rs2266782 was related to lower plasma TMAO levels.

关键词： chronic heart failure trimethylamine-N-oxide flavin monooxygenase 3 single nucleotide polymorphism